People are motivated to acquire self-evaluative information that favours themselves or information that confirms their present self-views. We proposed that par...

Finitary sketches, i.e., sketches with finite-limit and finite-colimit specifications, are proved to be as strong as geometric sketches, i.e., sketches with finite-limit and arbitrary colimit specifications. Categories sketchable by such sketches are fully characterized in the infinitary first-order logic: they are axiomatizable by σ-coherent theories, i.e., basic theories using finite conjunctions, countable disjunctions, and finite quantifications. The latter result is absolute; the equivalence of geometric and finitary sketches requires (in fact, is equivalent to) the non-existence of measurable cardinals.

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Aristotle sometimes claims that the perception of special perceptibles by their proper sense is unerring. This claim is striking, since it might seem that we quite often misperceive things like colours, sounds and smells. Aristotle also claims that the perception of common perceptibles is more prone to error than the perception of special perceptibles. This is puzzling in its own right, and also places constraints on the interpretation of. I argue that reading Alexander of Aphrodisias on perceptual error can help (...) to make good sense of both of Aristotle’s claims. (shrink)

In this paper, I offer a new solution to the old problem of how best to understand the meaning of the word ‘logos’ in the extant writings of Heraclitus, especially in fragments DK B1, B2 and B50. On the view I defend, Heraclitus was neither using the word in a perfectly ordinary way in these fragments, as some have maintained, nor denoting by it some kind of general principle or law governing change in the cosmos, as many have claimed. Rather, (...) I argue, Heraclitus deliberately traded on the ordinary use of the word in his time (to refer to a written or spoken presentation of things as ‘thus and so’) to denote the world’s constant presentation of itself as ‘thus and so’ to all of us in our experience – a kind of cosmic self-revelation. I show how this captures the sense in which ‘the logos’ is said to be ‘common’ (xunos) and to be the kind of thing most people fail to comprehend even before hearing Heraclitus’ own account, all without detaching Heraclitus’ use of the word from its ordinary contemporary meaning. This interpretation suggests Heraclitus was a thinker more centrally concerned with human (mis)understanding than with speculative cosmology. (shrink)

The sense of smell occupies a peculiar intermediate position within Aristotle's theory of sense perception: odours, like colours and sounds, are perceived at a distance through an external medium of air or water; yet in their nature they are intimately related to flavours, the proper objects of taste, which for Aristotle is a form of touch. In this paper, I examine Aristotle's claims about odour and smell, especially in De Anima II.9 and De Sensu 5, to see what light they (...) shed on his theory of sense perception more generally. In the first half, I argue that neither of the two most influential recent ways of understanding Aristotle's theory of perception can adequately account for what he says about the sense of smell. In the second half, I offer my own positive account, considering and resolving various puzzles raised by Aristotle's claims about the nature of odour and its relation to flavour. Finally, I conclude that Aristotle's discussions of odour and smell suggest a plausible and interesting way of understanding the relationship, on his view, between ordinary, material changes in the sense organs and the activation of the capacity to perceive, considered merely as such. (shrink)

In this paper I consider two related issues raised by Aristotle 's treatment of hearing and sounds. The first concerns the kinds of changes Aristotle takes to occur, in both perceptual medium and sense organs, when a perceiver hears a sounding object. The second issue concerns Aristotle 's views on the nature and location of the proper objects of auditory perception. I argue that Aristotle 's views on these topics are not what they have sometimes been taken to be, and (...) that when rightly understood they compare favourably in many respects with leading contemporary accounts. (shrink)

Aristotle is history’s most famous and influential proponent of the view that there are exactly five senses. But was he entitled to hold this view, given his other commitments? In particular, was he entitled to treat touch as a single sense, given the diversity of its correlated objects? In this paper I argue that Aristotle wished to individuate touch on the basis of its correlated objects, just as he had the other four senses. I also argue, contrary to what is (...) often supposed, that he was well-placed to do so, given his other commitments and views. (shrink)

In book 9 of Plato's Republic, Socrates describes the nature and origins of the ‘tyrannical man’, whose soul is said to be ‘like’ a tyrannical city. In this paper, I examine the nature of the ‘government’ that exists within the tyrannical man's soul. I begin by demonstrating the inadequacy of three potentially attractive views sometimes found in the literature on Plato: the view that the tyrannical man's soul is ruled by his ‘lawless’ unnecessary appetites, the view that it is ruled (...) by sexual desire, and the view that it is ruled by a lust for power. I then present my own account. On the view I defend, the tyrannical man's soul is to be understood as ruled by a single, persistent, powerful desire for bodily pleasure: as much as he can get, and however he can get it. Finally, I show how understanding the tyrannical man's soul in the way I recommend helps resolve some commonly expressed concerns about this part of the Republic. I suggest, on this basis, that Plato's procedure in constructing his catalogue o.. (shrink)

In De Anima II.6, Aristotle divides the objects of perception into three kinds: “special perceptibles" (idia aisthêta) such as colours, sounds and flavours, which can be perceived in their own right by only one sense; “common perceptibles" (koina aisthêta) such as shapes, sizes and movements, which can be perceived in their own right by multiple senses; and “incidental perceptibles,” such as the son of Diares, which can be perceived only “incidentally” (kata sumbebêkos). In this paper, I examine this division of (...) perceptibles and consider what it amounts to. First, I argue that Aristotle’s distinction between perceiving something in its own right (kath' hauto) and perceiving it incidentally marks a causal distinction: what is perceived in its own right causes perception as such, whereas what is perceived incidentally coincides with what is perceived in its own right. Second, I argue that for Aristotle special perceptibles, unlike common perceptibles, belong to homogeneous bodies on account of their chemical composition. Finally, I explain the primacy Aristotle assigns to special perceptibles and his claim that perception of them alone is free from error. I conclude with some brief remarks on Aristotle and the primary/secondary quality distinction. (shrink)

In this paper, I consider how each of the four main kinds of corrupt person described in Plato's Republic, Books 8-9, first comes to be. Certain passages in these books can give the impression that each person is able to determine, by a kind of rational choice, the overall government of his/her soul. However, I argue, this impression is mistaken. Upon careful examination, the text of books 8 and 9 overwhelmingly supports an alternative interpretation. According to this view, the eventual (...) government of each person’s soul is decided by a struggle for power occurring within the person, among the soul’s parts, the outcome of which is determined by the relative strength and alignment of the competing parties. If this interpretation is correct, Plato adheres more closely to the city-soul analogy in these passages than has sometimes been thought. The ultimate origins of vice in the soul are also seen to lie squarely in upbringing and education, not in a mistaken choice of life. (shrink)

I provide indestructibility results for large cardinals consistent with V = L, such as weakly compact, indescribable and strongly unfoldable cardinals. The Main Theorem shows that any strongly unfoldable cardinal κ can be made indestructible by <κ-closed. κ-proper forcing. This class of posets includes for instance all <κ-closed posets that are either κ -c.c, or ≤κ-strategically closed as well as finite iterations of such posets. Since strongly unfoldable cardinals strengthen both indescribable and weakly compact cardinals, the Main Theorem therefore makes (...) these two large cardinal notions similarly indestructible. Finally. I apply the Main Theorem forcing extension preserving all strongly unfoldable cardinals in which every strongly unfoldable cardinal κ is indestructible by <κ-closed. κ-proper forcing. (shrink)

Almost all the existing modern systems of Ethics deal with formal definitions, and at bottom repeat more or less the same thing about them in slightly different words. In this work these are a side issue, and therefore are treated briefly. Their treatment in Section I is based upon the author's theoretical works the Theory of Order and the Theory of Reality, but will be intelligible to those who are not acquainted with those works. The chief concern is moral teaching (...) - that is, the practical element. (shrink)

In Republic 8–9, Socrates describes four main kinds of vicious people, all of whose souls are “ruled” by an element other than reason, and in some of whom reason is said to be “enslaved.” What role does reason play in such souls? In this paper, I argue, based on Republic 8–9 and related passages, and in contrast to some common alternative views, that for Plato the “enslavement” of reason consists in this: instead of determining for itself what is good, reason (...) is forced to desire and pursue as good a goal determined by the soul’s ruler. (shrink)

This article explores emotions and their relationship to ‘somatic responses’, i.e., one’s automatic responses to sensations of pain, cold, warmth, sudden intensity. To this end, it undertakes a Husserlian phenomenological analysis of the first-hand experience of eight basic emotions, briefly exploring their essential aspects: their holistic nature, their identifying dynamic transformation of the lived body, their two-layered intentionality, their involuntary initiation and voluntary espousal. The fact that the involuntary tensional shifts initiating emotions are irreplicatable voluntarily, is taken to show that (...) all emotions have an innate core, a conclusion corroborated by their strong similarities to somatic responses in dynamics, hedonic tone, and topology. The fact that emotions may be culturally reworked, is shown to be explicable in terms of their complex nature: their dependence on belief, their voluntary espousal, and their ready social transmittability. Finally, it is argued that emotions may plausibly be deemed the evolutionary descendants of somatic responses. (shrink)

This paper considers dimensions of animate life that are readily “embodied” by phenomenologists and by other philosophy and science researchers as well. The paper demonstrates how the practice of “embodying” short-circuits veritable phenomenological accounts of experience through a neglect of attention to Husserl’s basic conception of, and consistent concern with, animate organism. The paper specifies how in doing so, the practice muddies a clear distinction between the body ‘I have’ and the body ‘I am’, and a clear account of their (...) lived conjunction in existential fit. In turn, the paper shows how the practice falls short of recognizing synergies of meaningful movement created by animate organisms; how it is tethered to talk of posture and sensation over kinesthesia and dynamics; and how, in general, the practice of embodying generates static rather than dynamic understandings of everyday life. The paper then critically considers how such liabilities preclude in-depth phenomenological insights into topics such as ‘ownership’ and ‘agency,’ and why inquiries into the nature of animate organisms require nothing less than fine-tuned attention to foundational experiences of animate life, including foundational ontogenetical experiences that undergird adult proficiencies and abilities, and hence fine-tuned attention to learning and to retaining what is learned in kinesthetic memory. (shrink)

This paper takes five different perspectives on kinesthesia, beginning with its evolution across animate life and its biological distinction from, and relationship to proprioception. It proceeds to document the historical derivation of “the muscle sense,” showing in the process how analytic philosophers bypass the import of kinesthesia by way of “enaction,” for example, and by redefinitions of “tactical deception.” The article then gives prominence to a further occlusion of kinesthesia and its subduction by proprioception, these practices being those of well-known (...) phenomenologists, practices that exemplify an adultist perspective supported in large part by the writings of Merleau-Ponty. Following this extended critical review, the article shows how Husserl’s phenomenology enlightens us about kinesthesia and in doing so offers us substantive clues to the phenomenology of learning as it takes place in the development and acquisition of skillful movement. It shows further how phenomenological methodology contrasts markedly with existential analysis, most significantly in its recognition of, and its ability to set forth a developmental history, a veritable genetic phenomenology that is basically a phenomenology of learning anchored in kinesthesia. After showing how that phenomenology of learning finds mutual validation in a classic empirical study of infant movement, the article ends by highlighting how human “I cans” are grounded in “I move,” specifically, in the pan-human ability to learn one’s body and learn to move oneself. (shrink)

This book argues the case for a foundationalist ethics centrally based on an empirical understanding of human nature. For Maxine Sheets-Johnstone, “an ethics formulated on the foundations of anything other than human nature, hence on anything other than an identification of pan-cultural human realities, lacks solid empirical moorings. It easily loses itself in isolated hypotheticals, reductionist scenarios, or theoretical abstractions—in the prisoner’s dilemma, selfish genes, dedicated brain modules, evolutionary altruism, or psychological egoism, for example—or it easily becomes itself an ethical (...) system over and above the ethics it formulates,” such as the deontological ethics of Kantian categorical imperatives, the utilitarianism of Bentham and Mill, or the ethics of care. Taking her cue from Hume, especially his _Treatise on Human Nature_, where he grounds “the moral sense” in human nature seen as always in tension between the natural tendencies of selfish acquisitiveness and sympathy for others, Sheets-Johnstone pursues her phenomenological investigation of the natural basis of human morality by directing her attention, first in Part I, to what is traditionally considered the dark side of human nature, and then, in Part II, to the positive side. The tension between the two calls for an interdisciplinary therapeutic resolution, which she offers in the Epilogue by arguing for the value of a moral education that enlightens humans about their own human nature, highlighting both the socialization of fear and the importance of play and creativity. (shrink)

The Yoga Sutras were formulated in India in the third century B.C. The word yoga is from the Sanskrit root meaning "join" or "unity, " and a sutra is a thread or aphoristic verse. Yoga itself is not associated with any particular religion; it simply offers techniques leading to the direct experience of truth. The basic questions Who am I? Where am I going? What is the purpose of life? are asked by every generation, and Patanjali's answers form one of (...) the world's oldest and most vibrant spiritual texts. He explains what yoga is, how it works, and exactly how to purify the mind and let it settle into absolute stillness. Alistair Shearer's extensive and helpful introduction and superb translation, fully preserving Patanjali's jewel-like style, bring these ancient but vital teachings to those who seek the path of self-knowledge today. (shrink)

My chief claim is that no one could understand the meaning of either 'consciousness' or 'unconsciousness' unless his consciousness had been interrupted on at least one occasion. I consider various attempts that might be made to teach the meanings of these terms to a person who had never lost consciousness, And I show how these attempts fail. The ideas of consciousness and unconsciousness can occur only to a person in whose experience there has been a gap.

Pluralism's renaissance, thanks to William Connolly, Chantal Mouffe and others, has established its position as the distinctive voice of late modern democracy. It thus calls for an explicit theory of tragedy to address the antagonisms and enmities it reflects and fosters. Treating Machiavelli, Rousseau, Nietzsche, Weber and Camus as members of a minor tradition of thought, I articulate a political conception of tragedy that flows not from the failures of politics but, ironically, from politics at its best. A tragic understanding (...) can provide a valuable re-description of intractable political conflicts that simultaneously de-moralizes them; it can also furnish vibrant ethical-political resources for an ethos of commitment and accountability suited to life in a democratic pluralist polity. Building on these thinkers, I propose the introduction of a Dionysian festival that subverts, even disables, mere patriotic celebration and turn to a classic in American cinema, The Man Who Shot Liberty Valance, to explore a tragic conception of political life that can be a source of inspiration and energy in a revitalized democratic community. (shrink)

By an “organism” I mean a living thing, in the most ordinary sense. There is an “organic theory of nature” in which the term “organism” is extended so as to include atoms, molecules, crystals, colloidal micelles, etc.; such constellations of parts have been called “inorganic organisms” by Driesch. I shall regard them as the “results of organization.” As we know them they are “models” , and they exist in the minds of physicists just as differential equations are in the minds (...) of mathematicians. They express arrangements just as a trade union is an arrangement, and just as artifacts, such as the nest of a chaffinch or the sleeping-bag of an Arctic explorer, are expressions of arrangements. (shrink)

Descriptive foundations and a concern with origins are integral to both Husserlian phenomenology and Darwinian evolutionary biology. These complementary aspects are rooted in the lifeworld as it is experienced. Detailed specifications of the complementary aspects testify to a mutual relevance of phenomenology to evolutionary biology and of evolutionary biology to phenomenology. Exemplifications of the mutual relevance are given in terms of both human and nonhuman agentive abilities. The experiential exemplifications show that agentive abilities are rooted in the kinetic sequence: I (...) move, I do, I can. The kinetic sequence in turn testifies to an ability to think in movement, a thinking that engenders corporeal concepts. It also, however, attests to the need for a veritable phenomenology of learning on the one hand and for a veritable recognition of mindful bodies on the other, mindful bodies that are a driving force both in the evolution of animate forms of life and in the evolution of repertoires of I cans. (shrink)

Recent neuropaleontological research suggests that the parietal lobe has increased in size as much as the frontal lobes in Homo Sapiens over the past 150,000 years, but has not provided a neuropsychological explanation for the evolution of human socialization or the development of religion. Drawing from several areas of research, (i.e., neurodevelopment, neuropsychology, paleoneurology, cognitive science, archeology, and anthropology), we argue that parietal evolution in Homo sapiens integrated sensations and mental processes into a more integrated subjective “sense of self”. This (...) enhanced self advanced prosocial traits (e.g., increased empathy, greater social bonding, enhanced theory of mind capacities), promoting more effective socialization skills (e.g., parenting, group cooperation). Conversely, when this enhanced sense of self became inhibited, powerful experiences of self-transcendence occurred. We believe these potent selfless experiences became increasingly sought after though ritual means (e.g., music, dance, vision quests, spirit travel), providing the foundations for the development of shamanism and religion. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

Section I details Husserl’s insight into style and how a person’s individual style is played out in affect and action and in the two‑fold articulation of perception and “the kinestheses,” both of which are integral to gestural communication. Section II details how the evolutionary perspectives of Darwin and linguistic scholars complement Husserl’s insights into the animate realities of gesture and bring to light further dimensions of human and nonhuman gestural practices and possibilities through extensive experiential accounts that document the essential (...) role of movement and thinking in movement in animate lives. Section III focuses on critical oversights by prominent phenomenologists who, rather than basing their studies in the rigors of phenomenological methodology, write of “what it is like” with respect to experience or give preferred opinions as in “consciousness of my gesture [...] can tell us nothing about movement.”. (shrink)

This article offers critical and constructive perspectives essential to understanding living bodies, and, in effect, to showing that kinesthesia, tactility and affectivity matter because they are central to animate life. Critical perspectives focus on practices that distance us from the lived realities of animate nature, on insights into those realities, and on ways in which language is intimately related to those realities. Constructive perspectives focus on ontogenetic studies that empirically testify to our being animate organisms from the start. The studies (...) validate Husserl’s insight into the developmental progression from ‘I move’ to ‘I do’ to ‘I can’. On the basis of these perspectives, concluding observations focus on the mutual validation of empirical and phenomenological research, on the distinction between movement and objects in motion, on the distinction between perceiving and feeling one’s body, and on the distinction between having a body and being a body. (shrink)

MATTER AND LIGHT The New Physics By LOUIS DE BROGLIE. Originally published in 1937. TRANSLATORS NOTE: THE Author has in certain places modified the original French text for the English translation, for the sake of greater cohesion, and has also revised some passages, in order to bring them into accord with the results of later research. Occasional Translators Notes are shown in square brackets. The chapter on The Undulatory Aspects of the Electron has the special historical interest of having been (...) delivered as a Lecture on the occasion of the Authors receipt of the Nobel Award, while that on Wave Mechanics and its Interpretations was given as an Address at the Glasgow meeting of the British Association in 1928. I am indebted to Dr. J. E. Turner, of the University of Liver pool, for assistance with the translation and the proofs, and to Dr. C. Strachan, of the same University, I am indebted for valuable assistance in dealing with the equations and the more technical passages, as well as for reading the proofs. W. H. J. PREFACE: THE amiable insistence of my friend Andr George has induced me to collect in the present Volume a number of Studies on con temporary Physics written from both the general and the more metaphysical point of view. Each of these Studies forms an inde pendent whole, and can be read by itself. A slight degree of repeti tion which the reader is asked to overlook has been the inevi table result for on more than one occasion I have been compelled to duplicate a summary of the great fundamental stages of con temporary Physics, such as the classification of simple substances, the investigation of the photo-electric effect and the origin of the Theory of Light Quanta and of Wave Mechanics the subjects are somewhat technical, and I cannot well assume that they are common knowledge. But though the same subject is outlined in several of these Studies, I have tried to take up a different point of view in each, and have endeavoured to throw light on different aspects of the essential problems of Quantum Physics in order to facilitate a grasp of their importance. On comparing the different chapters the reader will observe that, while overlapping, they also complement one another and he will feel the fascination and greatness inherent in the vast structure of modern Physics. And while admiring the vast number and the extreme delicacy of experimental facts which laboratory physicists have succeeded in revealing, and the strange and brilliant concepts devised by theorists to explain them, he will appreciate to what a degree the methods and ideas of physicists have grown in subtlety during recent years, and how great has been the progress from the somewhat ingenuous Realism and the over-simplified Mechanics of earlier thinkers. The more deeply we descend into the minutest structures of Matter, the more clearly we see that the concepts evolved by the mind in the course of everyday experience especially those of Time and Space must fail us in an endeavour to describe the new worlds which we are entering. One feels tempted to say that the outlines of our concepts must undergo a progressive blurring, in order that they may retain some semblance of relevance to the realities of the subatomic scales. Time and Space, in other words, are too loose a dress for the elementary entities individuality becomes attenuated in the mysterious pro cesses of interaction, and even Determinism, the darling of an older generation of physicists, is forced to yield... (shrink)

Nurses’ religious beliefs influence their motivations and perspectives, including their practice of ethics in nursing care. When the impact of these beliefs is not recognized, great potential for unethical nursing care exists. Thus, this article examines how the theology of one religious tradition, Seventh-day Adventism (SDA), could affect nurses. An overview of SDA history and beliefs is presented, which explains why ‘medical missionary’ work is central to SDAs. Theological foundations that would permeate an SDA nurse’s view of the nursing metaparadigm (...) concepts of person, health, environment (i.e. community), and nursing (i.e. service) are presented. The ethical principles guiding SDA nurses (i.e. principled, case-based, and care ethics) and the implications of these theological foundations for nurses are noted in a case study. (shrink)

Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required (...) for quality control because selective fusion is sufficient; (ii) increased connectivity may have non‐linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Whose Buddhism? Whose Identity? Presenting and/or Misrepresenting Shin Buddhism for a Christian AudienceAAR Panel on Multiple Religious Belonging and Buddhist Identity November, 2013Kristin Johnston Largenmultiple religious belongingThe concept of multiple religious belonging has become much more popular in the past ten years, both in academic discourse and in public practice, particularly in the United States. One of the most common “pairings” in this regard is Buddhism and Christianity. (...) Perhaps this is not surprising: Since at least the 1900s Christians have been fascinated with “oriental” religions in general and Buddhism in particular.1 And yet, here at the close of 2013, we can conclude that this fascination has not been unproblematic.It is fair to say that from their first introduction, Christians have regarded Buddhism more as a humanistic philosophy than as a religion (as that term typically is understood in a Western context) and consequently as not putting forth any exclusive truth claims.2 This idea has led to the assumption that Buddhism can be easily mined for self-improvement techniques and attitudes that can be smoothly integrated into a Christian framework.So, for example, Christian congregations and individuals alike pursue with alacrity meditation, mindfulness, and mantra recitation without much, if any, awareness of what they mean and how they function within a particular Buddhist context.3This has had negative ramifications for Christians and Buddhists alike, and even though Shin Buddhism has not been a frequent dialogue partner with Christianity, it is particular vulnerable to these kind of distortions, given the apparent resemblances between them. Dennis Hirota notes that [End Page 29]similarities with Christian teachings have often led to fundamental difficulties in expressing and understanding Shin thought in the context of dialogue with other religions. Because Shin Buddhist statements about reality and human engagement with it have seemed so similar in certain respects to some Christian doctrines, it has been assumed that the conceptions of truth are the same, and therefore such problems as the nature of religious engagement or the ontological status of a supreme being are the same.4In the same vein, Gregory Gibbs writes that “We cannot escape the tendency that many scholars will have to elaborate Shinshū against the backdrop of Christian thought. Alfred Bloom and Unno Taitetsu have each expressed reservations about ‘the recourse to traditions other than Shin to explain its basic teachings.’”5So, we find ourselves in a situation in which well-meaning Christian practitioners and academics, with the best of intentions, often seek to interpret Shin Buddhism through a Christian lens, such that it can be better understood, approached, and experienced by Christians. However, the linguistic and conceptual bridges that are built in this way unfortunately can distort the very ground on which they stand, facilitating a fabricated sense of multiple religious belonging by asserting false parallels. In my view, these bridges function more effectively when they are designed to facilitate a going out and a returning home [rather than travel to a new destination entirely], with the goal of what I might call a “Buddhist-infused” Christianity, which may well be both more authentic and more constructive than any “multiple” permutation of either.In light of all this, then, my paper proceeds as follows. I first examine the portrayal of Amida, both as described by Shinran himself, and also as depicted in the three Pure Land sutras.6 I then explore how Amida has been characterized for a Christian audience, demonstrating how descriptions of Amida often are couched in Christian theistic language, resulting in the fact that Amida looks uncannily similar to “God,” particularly when the understanding of Amida’s relationship to those who invoke his name is defined using a christological and soteriological model.7 I then turn to the important concept of shinjin, arguing that the popular translation of shinjin as “faith” only furthers the assumption that Christianity and Shin Buddhism make the same basic claims about human existence.who is amida buddha?Beginning with Shinran and Shin Buddhism, the first thing that must be emphasized is that, according to The Larger Sutra on Amitāyus, Amida Buddha is not a “god,” as Christians understand the term, but originally, at... (shrink)

A while ago I pulled the short straw, and became chair of my department. One nice part of the job is to praise people I work with, which I can do sincerely because they are very praiseworthy. I also have to read a lot of praise by others; the familiar things—project evaluations, letters of recommendation, promotion dossiers, and so on and so forth. As a result, I have learnt to attend to praise a little more closely.

This article proposes that cosmetic minimally-invasive procedures – Botox injections, soft-tissue fillers, microdermabrasion, chemical peels and laser treatments – are an under-researched area and provide a number of promising paths for skin studies research. I argue that cosmetic minimally-invasive procedures collapse the difference between the surfaces of the photograph and the skin – the primary surfaces of cosmetic surgery – more successfully than cosmetic surgical procedures. More precisely, I maintain that the difference between photograph and skin is collapsed in two (...) ways: first, through narrating the transformation of the skin’s surface in a way that more closely matches the photographic promises of the cosmetic surgery industry; and, second, by depicting the surgical penetration of the skin through advertising photography. The article concludes by suggesting that further investigation into cosmetic minimally-invasive procedures could offer a new way to think about relationships between ‘normative’ and ‘non-normative’ skin modification practices. (shrink)

The world-view to which the long arc of modern philosophy since Descartes bends is Materialism With A Bad Conscience, a Materialism continually bedeviled by the need to deal with apparently irreducible mental items. I believe this world-view to be the offspring of an introjective error; in effect, the mentalization of sensible form, finality and value. Hence the characteristic modernist accusation is that when we take sensible form, finality and value to be genuine features of the manifest we are thereby "projecting" (...) aspects of our mental life onto an environment devoid of these features. David Hume went furthest in this Projectivist direction arguing that indeed even the very notion of an efficient cause was a projection of our habitual expectations that the regularly observed consequences of certain classes of events would continue. So far from these expectations constituting a practical knowledge of efficient causes, acquired over immense periods of time in the life of our species as it adapted to and with its complex causal environment, those expectations are merely appearances which we mistake for a mind-independent relation among the things themselves. Thus the manifest is traded in for the "manifest image of the world," an image interposed between a subject and deracinated environment. (shrink)

God’s creative act, if genuinely free, would ground the existence of creatures without necessitating them. Since God is perfectly responsive to reason, his freely creating requires that he have an adequate but non-coercive reason to create. A coercive reason for an act is one that outweighs the reasons for any alternative act, whereas an adequate reason is one that is not outweighed by the reasons in favor of any alternative act. How, in the absence of an offsetting reason not to (...) create, is God’s adequate reason not also a coercive reason, i.e., one that would necessitate creation? Chapter 7 argues that God’s creating and God’s remaining within himself each have to be understood as determinate manners in which God may affirm his own unsurpassable goodness. Cantorian reflections are then deployed to explain how God’s extra, i.e., un-offset, reason to create does not give him more of a reason to create than to not create. Finally, God’s actual reason to create is identified. (shrink)

ABSTRACT:Programs aimed at increasing women’s entrepreneurship are a rapidly proliferating class of CSR initiatives across the globe with participation by many of the world’s largest corporations. The gendered nature of this phenomenon suggests that feminist approaches to CSR may offer a particularly salient mode of their analysis. In this article, I argue that insights from feminist economics regarding the historically prevalent—but narrow and gendered—definition of work, which artificially separates production from reproduction, provide fruitful tools for theory building when conceptualizing gender (...) through the lens of CSR. I demonstrate that the gendered separation of production and reproduction is typicallytaken as givenin entrepreneurship, and that mainstream CSR research has not sufficiently challenged this perspective. I present a conceptual framework of what is to be gained by examining the CSR, entrepreneurship, and feminist economics literatures in combination, and demonstrate how researchers might use this framework for future research. (shrink)

The Australian Royal Commission into Aged Care Quality and Safety acknowledged understaffing and substandard care in residential aged care and home care services, and recommendations were made that that the Australian Government should promote assistive technology within aged care. Robotic care assistants can provide care and companionship for the elderly—both in their own homes and within health and aged care institutions. Although more research is required into their use, studies indicate benefits, including enabling the elderly to live independently at home, (...) assistance with medication and monitoring of safety. Nevertheless, there are inherent ethical challenges in the use of robots as carers, including loss of privacy, unwarranted restrictions on autonomy, lack of dignity, deception, and the exacerbation of loneliness. Ethics by design can counter these issues in development of robotics and clinical ethics committees have been put forward as a way of dealing with the ethical use of robotic care in healthcare institutions. In this paper I outline the ethical challenges of robotic care assistants and how these may be mediated in their design and use. (shrink)

The world-view to which the long arc of modern philosophy since Descartes bends is Materialism With A Bad Conscience, a Materialism continually bedeviled by the need to deal with apparently irreducible mental items. I believe this world-view to be the offspring of an introjective error; in effect, the mentalization of sensible form, finality and value. Hence the characteristic modernist accusation is that when we take sensible form, finality and value to be genuine features of the manifest we are thereby "projecting" (...) aspects of our mental life onto an environment devoid of these features. David Hume went furthest in this Projectivist direction arguing that indeed even the very notion of an efficient cause was a projection of our habitual expectations that the regularly observed consequences of certain classes of events would continue. So far from these expectations constituting a practical knowledge of efficient causes, acquired over immense periods of time in the life of our species as it adapted to and with its complex causal environment, those expectations are merely appearances which we mistake for a mind-independent relation among the things themselves. Thus the manifest is traded in for the "manifest image of the world," an image interposed between a subject and deracinated environment. (shrink)

ABSTRACT Frege characterizes judgement as the acknowledgement of the truth of a thought, appearing thereby to rule out false judgement. First in this paper I explain Frege’s characterization so that it does not have this consequence. Frege is not saying that for a subject S to judge that p is for S to acknowledge the truth of the thought that p. Rather, he is articulating judgement’s nature within self-consciousness. From within, to judge means to acknowledge a truth. Second, I suggest (...) that this articulation is centrally operative in Frege’s argument for the indefinability of truth. As Frege argues, it follows from judgement’s self-consciousness that truth is indefinable. (shrink)

My task in this paper is to demonstrate, contra Nel Noddings, that Kantian ethics does not have an expectation of treating those closest to one the same as one would a stranger. In fact, Kantian ethics has what I would consider a robust statement of how it is that those around us come to figure prominently in the development of one's ethics. To push the point even further, I argue that Kantian ethics has an even stronger claim to treating those (...) closest to oneself as imperative than Noddings and sentiment-based ethical theory in general, proposes. (shrink)

In books 8 and 9 of Plato’s Republic, Socrates provides a detailed account of the nature and origins of four main kinds of vice found in political constitutions and in the kinds of people that correspond to them. The third of the four corrupt kinds of person he describes is the ‘democratic man’. In this paper, I ask what ‘rules’ in the democratic man’s soul. It is commonly thought that his soul is ruled in some way by its appetitive part, (...) or by a particular class of appetitive desires. I reject this view, and argue instead that his soul is ruled by a succession of desires of a full range of different kinds. I show how this view helps us better understand Plato’s depiction of corrupt souls in the Republic more generally, and with it his views on the rule of the soul, appetitive desire, and the nature of vice. (shrink)

Although it is common for interpreters of Aristotle's De Anima to treat the soul as a specially related set of powers of capacities, I argue against this view on the grounds that the plausible options for reconciling the claim that the soul is a set of powers with Aristotle's repeated claim that the soul is an actuality cannot be unsuccessful. Moreover, I argue that there are good reasons to be wary of attributing to Aristotle the view that the soul is (...) a set of powers because this claim conflicts with several of his metaphysical commitments, most importantly his claims about form and substance. I argue that although there are passages in the De Anima in which Aristotle discusses the soul in terms of its powers or capacities, these discussions do not establish that the soul is a set of capacities. (shrink)

My task in this paper is to demonstrate, contra Nel Noddings, that Kantian ethics does not have an expectation of treating those closest to one the same as one would a stranger. In fact, Kantian ethics has what I would consider a robust statement of how it is that those around us come to figure prominently in the development of one's ethics. To push the point even further, I argue that Kantian ethics has an even stronger claim to treating those (...) closest to oneself as imperative than Noddings and sentiment‐based ethical theory in general, proposes. (shrink)

Recent books by Paul Johnston, D. Z. Phillips, Philip Shields, and B. R. Tilghman all depict Wittgenstein as centrally concerned with ethics, but they range from representing his main works as expressing and advocating a particular religious-ethical outlook to arguing that his work has no ethical content but aims primarily to clarify such logical distinctions as that between ethical and empirical judgments. All four books raise the question about the moral philosopher's proper role, and each suggests a rather different (...) answer. Via the discussion of these books, I argue that Wittgenstein's stress on diversity in the ways of human life, his notion of conceptual grammar, the idea of a perspicuous representation, his lifelong involvement with art and his suggestions about its connection with morality, and his preoccupation with aspect-seeing-all suggest new possibilities of rehabilitating the historically recurrent idea that the philosopher may be a moral sage. (shrink)

Introduction; "One surely will be found one day to make an ontology with what I am telling you": the road to a post-Lacanian materialism -- Part One. Jacques Lacan: between the sacred and the secular -- 1. Conflicted matter: the challenge of secularizing materialism -- 2. Turning the sciences inside out: revisiting "Science and truth" -- 3. On deep history and psychoanalysis: phylogenetic time in Lacanian theory --Part Two. Alain Badiou: between form and matter -- 4. What matter(s) in ontology: (...) the Hebb-event and materialism split from within -- 5. Phantom of consistency: Kant troubles -- Part Three. Quentin Meillassoux: between faith and knowledge -- 6. The world before worlds: the ancestral and Badiou's anti-Kantian transcendentalism -- 7. Hume's revenge: a Dieu, Meillassoux? -- Postface: from critique to construction: toward a transcendental materialism. (shrink)

Aristotle claims, in his Nicomachean Ethics, that in addition to being, for example, just and courageous, and temperate, the virtuous person will also be witty. Very little sustained attention, however, has been devoted to explicating what Aristotle means when he claims that virtuous persons are witty or to justifying the plausibility of the claim that wittiness is a virtue. It becomes especially difficult to see why Aristotle thinks that being witty is a virtue once it becomes clear that Aristotle’s witty (...) person engages in what he calls ‘educated insolence’. Insolence, for Aristotle, is a form of slighting which, as he explains in the Rhetoric, generally causes the person slighted to experience shame and anger. In this paper, I attempt to bring some clarity to Aristotle’s claim that being witty is a virtue by examining why Aristotle thinks that the object of a witty person’s raillery will find this joking pleasant. (shrink)

Attempts to articulate the ways in which membership in socially subordinated social identities can impede one's autonomy have largely unfolded as part of the debate between different types of internalist theories in relation to the problem of internalized oppression. The different internalist positions, however, employ a damage model for understanding the role of social subordination in limiting autonomy. I argue that we need an externalist condition in order to capture the ways in which membership in a socially subordinated identity can (...) constrain one's autonomy, even if one is undamaged in one's autonomy competencies and self-reflexive attitudes. I argue that living among those practically empowered to harass, to engage in racial profiling, and to treat as expendable is incompatible with a freedom-condition required for unconstrained global self-determination. (shrink)